The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.
BACKGROUND: The vaccinia-related kinase 1 (VRK1) protein, an activator of p53, can be proteolytically downregulated by an indirect mechanism, which requires p53-dependent transcription. PRINCIPAL FINDINGS: In this work we have biochemically characterized the contribution of several p53 transcription...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2441436?pdf=render |