The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.

The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.

BACKGROUND: The vaccinia-related kinase 1 (VRK1) protein, an activator of p53, can be proteolytically downregulated by an indirect mechanism, which requires p53-dependent transcription. PRINCIPAL FINDINGS: In this work we have biochemically characterized the contribution of several p53 transcription...

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Bibliographic Details
Main Authors: Alberto Valbuena, Sandra Blanco, Francisco M Vega, Pedro A Lazo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2441436?pdf=render

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