CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation

CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation

Abstract Background Osteosarcoma (OS) is the most common malignant bone tumor with a high incidence in children and adolescents. Frequent tumor metastasis and high postoperative recurrence are the most common challenges in OS. However, detailed mechanism is largely unknown. Methods We examined the e...

Full description

Bibliographic Details
Main Authors: Shiqi Lu, Tong Lu, Jiayu Zhang, Lunbiao Gan, Xinjie Wu, Donghui Han, Keying Zhang, Chao Xu, Shaojie Liu, Weijun Qin, Fa Yang, Weihong Wen
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Cancer
Subjects:
Endosialin/CD248/TEM-1
Osteosarcoma
Migration
Metastasis
ITGB1
Online Access:https://doi.org/10.1186/s12885-023-10731-7

Internet

https://doi.org/10.1186/s12885-023-10731-7

Similar Items