CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation

CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation

Abstract Background Osteosarcoma (OS) is the most common malignant bone tumor with a high incidence in children and adolescents. Frequent tumor metastasis and high postoperative recurrence are the most common challenges in OS. However, detailed mechanism is largely unknown. Methods We examined the e...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Shiqi Lu, Tong Lu, Jiayu Zhang, Lunbiao Gan, Xinjie Wu, Donghui Han, Keying Zhang, Chao Xu, Shaojie Liu, Weijun Qin, Fa Yang, Weihong Wen
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: BMC 2023-03-01
Cyfres:BMC Cancer
Pynciau:
Endosialin/CD248/TEM-1
Osteosarcoma
Migration
Metastasis
ITGB1
Mynediad Ar-lein:https://doi.org/10.1186/s12885-023-10731-7

Rhyngrwyd

https://doi.org/10.1186/s12885-023-10731-7

Eitemau Tebyg