In vitro and in vivo modulation of LPS and carrageenan-induced expression of inflammatory genes by amitriptyline

In vitro and in vivo modulation of LPS and carrageenan-induced expression of inflammatory genes by amitriptyline

Context: Amitriptyline, a tricyclic antidepressant is used for the management of psychological disorders and various types of pain. In the previous work, it is founded that amitriptyline inhibited the migration of polymorphonuclear (PMN) into the site of inflammation. Aims: To evaluate the effect...

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Bibliographic Details
Main Authors: Laleh Rafiee, Valiollah Hajhashemi, Shaghayegh Haghjooy Javanmard
Format: Article
Language:English
Published: GarVal Editorial Ltda. 2017-06-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
amitriptyline
cyclooxygenase 2
inducible nitric oxide synthase
inflammation
intercellular adhesion molecule-1
vascular cell adhesion molecule-1
Online Access:http://jppres.com/jppres/pdf/vol5/jppres16.172_5.3.144.pdf

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http://jppres.com/jppres/pdf/vol5/jppres16.172_5.3.144.pdf

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