Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme

Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme

Oxidized hemoglobin induces polyreactivity and autoreactivity of human IgG through direct transfer and binding of heme to the variable region of IgG, which contributes to a better understanding of the physiopathology of hemolytic diseases.

Bibliographic Details
Main Authors: Cyril Planchais, Remi Noe, Marie Gilbert, Maxime Lecerf, Srini V. Kaveri, Sébastien Lacroix-Desmazes, Lubka T. Roumenina, Jordan D. Dimitrov
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04535-5

Internet

https://doi.org/10.1038/s42003-023-04535-5

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