Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors

Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors

Abstract Background New therapies are urgently needed in melanoma, particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. To uncover novel potentiators of T cell anti-tumor immunity, we carried out an ex vivo pharmacological screen and identified 5-Nonyloxytrypt...

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Bibliographic Details
Main Authors: Paweł Stachura, Wei Liu, Haifeng C. Xu, Agnès Wlodarczyk, Olivia Stencel, Piyush Pandey, Melina Vogt, Sanil Bhatia, Daniel Picard, Marc Remke, Karl S. Lang, Dieter Häussinger, Bernhard Homey, Philipp A. Lang, Arndt Borkhardt, Aleksandra A. Pandyra
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Cancer
Subjects:
CD8+ T cells
Immunotherapy
Antigen-presenting machinery
5-Nonyloxytryptamine (5-NL)
Cold tumors
cAMP response element-binding protein (CREB)
Online Access:https://doi.org/10.1186/s12943-023-01833-8

Internet

https://doi.org/10.1186/s12943-023-01833-8

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