Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.
The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is linked to polycomb gene silencing in Drosophila. However, it has not been reported to mediate heterochromatin formation...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-03-01
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| Series: | PLoS Genetics |
| Online Access: | http://dx.doi.org/10.1371/journal.pgen.0020040 |