Synthesis, Structure and Molecular Docking of New 4,5-Dihydrothiazole Derivatives Based on 3,5-Dimethylpyrazole and Cytisine and Salsoline Alkaloids

Synthesis, Structure and Molecular Docking of New 4,5-Dihydrothiazole Derivatives Based on 3,5-Dimethylpyrazole and Cytisine and Salsoline Alkaloids

The interaction results of 1,2-dibromo-3-isothiocyanatopropane with some pyrazoles as well as cytisine and salsoline alkaloids were presented in this paper. It was shown that the reaction resulted in one one-step and rather mild method for the preparation of the corresponding 1,3-thiazoline bromomet...

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Bibliographic Details
Main Authors: Marat K. Ibrayev, Oralgazy A. Nurkenov, Zhanar B. Rakhimberlinova, Altynaray T. Takibayeva, Irina V. Palamarchuk, Dastan M. Turdybekov, Assel A. Kelmyalene, Ivan V. Kulakov
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
allylisothiocyanate
1,2-dibromo-3-isothiocyanatopropane
3,5-dimethyl-1<i>H</i>-pyrazole
intramolecular heterocyclization
5-(bromomethyl)-2-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-4,5-dihydrothiazole
cytisine and salsoline alkaloids
Online Access:https://www.mdpi.com/1420-3049/27/21/7598

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