Intravenous ganaxolone in pediatric super-refractory status epilepticus: A single hospital experience

Intravenous ganaxolone in pediatric super-refractory status epilepticus: A single hospital experience

Synaptic GABAA receptor (GABAAR) internalization contributes to the drug resistant nature of super-refractory status epilepticus (SRSE). Ganaxolone is a 3β-methylated synthetic analog of the endogenous neuroactive steroid, allopregnanolone, that has positive allosteric modulatory activity on synapti...

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Bibliographic Details
Main Authors: Rani K. Singh, Rajdeep Singh, Alejandra Stewart, Katherine Van Poppel, Sarah Klinger, Joseph Hulihan, Heather Van Heusen, Henrikas Vaitkevicius, Maciej Gasior
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Epilepsy & Behavior Reports
Subjects:
Status epilepticus
Super-refractory status epilepticus
Pediatric
Neurosteroids
Online Access:http://www.sciencedirect.com/science/article/pii/S2589986422000442

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http://www.sciencedirect.com/science/article/pii/S2589986422000442

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