Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro

Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro

Abstract Background Combined chemoradiation offers a promising therapeutic strategy for dogs with glioma. The alkylating agents temozolomide (TMZ) and lomustine (CCNU) penetrate the blood‐brain barrier, and doses for dogs are established. Whether such combinations are clinically advantageous remains...

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Bibliographic Details
Main Authors: Daniel Fuchs, Carla Rohrer Bley, Luca Morandi, Caterina Tonon, Mathias S. Weyland, Katarzyna J. Nytko
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Veterinary Medicine and Science
Subjects:
brain tumour
chemoradiation
dog
in vitro
O‐6‐methylguanine‐DNA methyltransferase (MGMT)
Online Access:https://doi.org/10.1002/vms3.1181

Internet

https://doi.org/10.1002/vms3.1181

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