The soluble recombinant Neisseria meningitidis adhesin NadA(Δ351-405) stimulates human monocytes by binding to extracellular Hsp90.

The soluble recombinant Neisseria meningitidis adhesin NadA(Δ351-405) stimulates human monocytes by binding to extracellular Hsp90.

The adhesin NadA favors cell adhesion/invasion by hypervirulent Neisseria meningitidis B (MenB). Its recombinant form NadA(Δ351-405,) devoid of the outer membrane domain, is an immunogenic candidate for an anti-MenB vaccine able to stimulate monocytes, macrophages and dendritic cells. In this study...

Full description

Bibliographic Details
Main Authors: Paola Cecchini, Regina Tavano, Patrizia Polverino de Laureto, Susanna Franzoso, Cristina Mazzon, Paolo Montanari, Emanuele Papini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3175003?pdf=render

Internet

http://europepmc.org/articles/PMC3175003?pdf=render

Similar Items