Insights into Domain Organization and Regulatory Mechanism of Cystathionine Beta-Synthase from <i>Toxoplasma gondii</i>

Insights into Domain Organization and Regulatory Mechanism of Cystathionine Beta-Synthase from <i>Toxoplasma gondii</i>

Cystathionine beta-synthase (CBS) is a key regulator of homocysteine metabolism. Although eukaryotic CBS have a similar domain architecture with a catalytic core and a C-terminal Bateman module, their regulation varies widely across phyla. In human CBS (HsCBS), the C-terminus has an autoinhibitory e...

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Bibliographic Details
Main Authors: Carolina Conter, Silvia Fruncillo, Filippo Favretto, Carmen Fernández-Rodríguez, Paola Dominici, Luis Alfonso Martínez-Cruz, Alessandra Astegno
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
cystathionine beta-synthase
<i>Toxoplasma gondii</i>
Bateman module
mutagenesis
enzyme activation
oligomerization
Online Access:https://www.mdpi.com/1422-0067/23/15/8169

Internet

https://www.mdpi.com/1422-0067/23/15/8169

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