Single-Cell Transcriptomics Reveals Killing Mechanisms of Antitumor Cytotoxic CD4+ TCR-T Cells

Single-Cell Transcriptomics Reveals Killing Mechanisms of Antitumor Cytotoxic CD4+ TCR-T Cells

T cell receptor-engineered T cells (TCR-Ts) have emerged as potent cancer immunotherapies. While most research focused on classical cytotoxic CD8+ T cells, the application of CD4+ T cells in adoptive T cell therapy has gained much interest recently. However, the cytotoxic mechanisms of CD4+ TCR-Ts h...

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Bibliographic Details
Main Authors: Yanling Liang, Qumiao Xu, Songming Liu, Jie Li, Fei Wang, Ziyi Li, Lijuan Liao, Yuting Lu, Yijian Li, Feng Mu, Hai-Xi Sun, Linnan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
cytotoxic CD4+ T
TCR-T
single-cell RNA sequencing
adoptive T cell therapy
LTA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.939940/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.939940/full

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