Depletion and activation of microglia impact metabolic connectivity of the mouse brain

Depletion and activation of microglia impact metabolic connectivity of the mouse brain

Highlights Microglial activation influences metabolic connectivity. Microglial depletion results in distinct decreases of metabolic connectivity. Metabolic connectivity increases in progranulin deficient mice. Cellular FDG allocation in progranulin deficient mice is shifted to microglia.

Bibliographic Details
Main Authors: Johannes Gnörich, Anika Reifschneider, Karin Wind, Artem Zatcepin, Sebastian T. Kunte, Philipp Beumers, Laura M. Bartos, Thomas Wiedemann, Maximilian Grosch, Xianyuan Xiang, Maryam K. Fard, Francois Ruch, Georg Werner, Mara Koehler, Luna Slemann, Selina Hummel, Nils Briel, Tanja Blume, Yuan Shi, Gloria Biechele, Leonie Beyer, Florian Eckenweber, Maximilian Scheifele, Peter Bartenstein, Nathalie L. Albert, Jochen Herms, Sabina Tahirovic, Christian Haass, Anja Capell, Sibylle Ziegler, Matthias Brendel
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Neuroinflammation
Subjects:
FDG–PET
Neurodegeneration
Microglia
Metabolic connectivity
scRadiotracing
Online Access:https://doi.org/10.1186/s12974-023-02735-8

Internet

https://doi.org/10.1186/s12974-023-02735-8

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