Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction

Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction

Abstract Background and Aims The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigat...

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Bibliographic Details
Main Authors: Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, Michelle Chew, Alexandru Schiopu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Critical Care
Subjects:
S100A8/A9
Sepsis-induced myocardial dysfunction
Endotoxemia
Mitochondrial function
Inflammation
Neutrophils
Online Access:https://doi.org/10.1186/s13054-023-04652-x

Internet

https://doi.org/10.1186/s13054-023-04652-x

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