AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer
Abstract Oncogenic activation of PI3K/AKT signaling pathway, together with epigenetic aberrations are the characters of castration-resistant prostate cancer (CRPC). UHRF1 as a key epigenetic regulator, plays a critical role in prostate cancer (PCa) development, and its expression is positively corre...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-01-01
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| Series: | Oncogenesis |
| Online Access: | https://doi.org/10.1038/s41389-022-00446-y |