σE of Streptomyces coelicolor can function both as a direct activator or repressor of transcription

Abstract σ factors are considered as positive regulators of gene expression. Here we reveal the opposite, inhibitory role of these proteins. We used a combination of molecular biology methods and computational modeling to analyze the regulatory activity of the extracytoplasmic σE factor from Strepto...

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Bibliographic Details
Main Authors: Jiří Pospíšil, Marek Schwarz, Alice Ziková, Dragana Vítovská, Miluše Hradilová, Michal Kolář, Alena Křenková, Martin Hubálek, Libor Krásný, Jiří Vohradský
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05716-y