Vegetable Oil-Peroxidation Product ‘Hydroxynonenal’ Causes Hepatocyte Injury and Steatosis via Hsp70.1 and BHMT Disorders in the Monkey Liver

Vegetable Oil-Peroxidation Product ‘Hydroxynonenal’ Causes Hepatocyte Injury and Steatosis via Hsp70.1 and BHMT Disorders in the Monkey Liver

Hsp70.1 has a dual function as a chaperone protein and lysosomal stabilizer. In 2009, we reported that calpain-mediated cleavage of carbonylated Hsp70.1 causes neuronal death by inducing lysosomal rupture in the hippocampal CA1 neurons of monkeys after transient brain ischemia. Recently, we also rep...

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Bibliographic Details
Main Authors: Tetsumori Yamashima, Yurie Mori, Takuya Seike, Sharif Ahmed, Piyakarn Boontem, Shihui Li, Shinji Oikawa, Hatasu Kobayashi, Tatsuya Yamashita, Mitsuru Kikuchi, Shuichi Kaneko, Eishiro Mizukoshi
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Nutrients
Subjects:
betaine-homocysteine <i>S</i>-methyltransferase
<i>calpain-cathepsin hypothesis</i>
carbonylation
cell death
lysosomal rupture
phosphatidylcholine
Online Access:https://www.mdpi.com/2072-6643/15/8/1904

Internet

https://www.mdpi.com/2072-6643/15/8/1904

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