Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow

Increased deformations are dispensable for encapsulated cell mechanoresponse in engineered bone analogs mimicking aging bone marrow

Aged individuals and astronauts experience bone loss despite rigorous physical activity. Bone mechanoresponse is in-part regulated by mesenchymal stem cells (MSCs) that respond to mechanical stimuli. Direct delivery of low intensity vibration (LIV) recovers MSC proliferation in senescence and simula...

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Bibliographic Details
Main Authors: Alexander M. Regner, Maximilien DeLeon, Kalin D. Gibbons, Sean Howard, Derek Q. Nesbitt, Seyedeh F. Darghiasi, Anamaria G. Zavala, Trevor J. Lujan, Clare K. Fitzpatrick, Mary C. Farach-Carson, Danielle Wu, Gunes Uzer
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Mechanobiology in Medicine
Subjects:
Mechanical signals
Low-intensity vibration
Mesenchymal stem cells
3D printing
Mechanical modeling
Tissue modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2949907024000603

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http://www.sciencedirect.com/science/article/pii/S2949907024000603

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