Mathematical topology and geometry-based classification of tauopathies

Abstract Neurodegenerative diseases, like Alzheimer’s, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. While it is known that different morphologies of tau filaments characterize different neurodegenerative diseases, there are few m...

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Bibliographic Details
Main Authors: Masumi Sugiyama, Kenneth S. Kosik, Eleni Panagiotou
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-58221-5