Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

Abstract Background Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improves the efficiency of induced pluripotent stem cell...

Full description

Bibliographic Details
Main Authors: Kevin C. L. Cheng, Jennifer M. Frost, Francisco J. Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Wan R. Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam Ewing, José L. García-Pérez, Miguel R. Branco
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Epigenetics & Chromatin
Subjects:
Vitamin C
LINE-1
Embryonic stem cells
Mouse
Human
2-oxoglutarate-dependent dioxygenases
Online Access:https://doi.org/10.1186/s13072-023-00514-6

Internet

https://doi.org/10.1186/s13072-023-00514-6

Similar Items