Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation

Abstract Background Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improves the efficiency of induced pluripotent stem cell...

詳細記述

書誌詳細
主要な著者: Kevin C. L. Cheng, Jennifer M. Frost, Francisco J. Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Wan R. Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam Ewing, José L. García-Pérez, Miguel R. Branco
フォーマット: 論文
言語:English
出版事項: BMC 2023-10-01
シリーズ:Epigenetics & Chromatin
主題:
Vitamin C
LINE-1
Embryonic stem cells
Mouse
Human
2-oxoglutarate-dependent dioxygenases
オンライン･アクセス:https://doi.org/10.1186/s13072-023-00514-6

インターネット

https://doi.org/10.1186/s13072-023-00514-6

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