Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
Abstract Background Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improves the efficiency of induced pluripotent stem cell...
Main Authors: | Kevin C. L. Cheng, Jennifer M. Frost, Francisco J. Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Wan R. Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam Ewing, José L. García-Pérez, Miguel R. Branco |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-10-01
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Series: | Epigenetics & Chromatin |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13072-023-00514-6 |
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