Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice

Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice

Background The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms of Leigh syndrome, the Ndufs4 k...

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Bibliographic Details
Main Authors: Mei Wang, Ya-Ping Huang, Han Wu, Ke Song, Cong Wan, A-Ni Chi, Ya-Mei Xiao, Xiao-Yang Zhao
Format: Article
Language:English
Published: PeerJ Inc. 2017-05-01
Series:PeerJ
Subjects:
Mitochondria complex I
Ndufs4
CRISPR/Cas9
Embryo development
Online Access:https://peerj.com/articles/3339.pdf

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https://peerj.com/articles/3339.pdf

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