From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy

From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy

Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder that is characterized pathologically by the loss of A9-specific dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the etiology of PD is currently unresolved, and the d...

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Bibliographic Details
Main Authors: Yee Jie Yeap, Tng J. W. Teddy, Mok Jung Lee, Micaela Goh, Kah Leong Lim
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s Disease
pluripotent stem cells
dopaminergic neurons
organoids
mesencephalon
midbrain
Online Access:https://www.mdpi.com/1422-0067/24/3/2523

Internet

https://www.mdpi.com/1422-0067/24/3/2523

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