Why estimands are needed to define treatment effects in clinical trials

Why estimands are needed to define treatment effects in clinical trials

Abstract Background The estimand for a clinical trial is a precise definition of the treatment effect to be estimated. Traditionally, estimates of treatment effects are based on either an ITT analysis or a per-protocol analysis. However, there are important clinical questions which are not addressed...

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Bibliographic Details
Main Authors: Oliver N. Keene, Helle Lynggaard, Stefan Englert, Vivian Lanius, David Wright
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Medicine
Subjects:
Estimand
Treatment effect
Intercurrent event
ITT
Per-protocol
PICO
Online Access:https://doi.org/10.1186/s12916-023-02969-6

Internet

https://doi.org/10.1186/s12916-023-02969-6

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