Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis

Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis

Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive sleep apnea (OSA), known to be independently associated with cardiovascular diseases. However, the effect of IH on cardiac fibrosis and molecular events involved in this process are unclear. Here, we tested IH...

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Bibliographic Details
Main Authors: Qiankun Bao, Bangying Zhang, Ya Suo, Chen Liu, Qian Yang, Kai Zhang, Ming Yuan, Meng Yuan, Yue Zhang, Guangping Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
intermittent hypoxia
cardiac fibrosis
cardiac fibroblast activation
STAT3
TSP1
Online Access:https://elifesciences.org/articles/49923

Internet

https://elifesciences.org/articles/49923

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