Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment

Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment

ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic betacoronaviruses that continue to have a significant impact on public health. Timely development and introduction of vaccines and antivirals against SARS-CoV...

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Bibliographic Details
Main Authors: Pengfei Li, Yunjeong Kim, Chamandi S. Dampalla, Harry Nhat Nguyen, David K. Meyerholz, David K. Johnson, Scott Lovell, William C. Groutas, Stanley Perlman, Kyeong-Ok Chang
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
protease inhibitors
3CLpro
SARS-CoV-2
MERS-CoV
animal models
Online Access:https://journals.asm.org/doi/10.1128/mbio.02878-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02878-23

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