Doxycycline Attenuates Cancer Cell Growth by Suppressing NLRP3-Mediated Inflammation

Doxycycline Attenuates Cancer Cell Growth by Suppressing NLRP3-Mediated Inflammation

NLR family pyrin domain containing 3 (NLRP3) inflammasome formation is triggered by the damaged mitochondria releasing reactive oxygen species. Doxycycline was shown to regulate inflammation; however, its effect on NLRP3 in cancer remains largely unknown. Therefore, we sought to determine the effect...

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Bibliographic Details
Main Authors: Mohammad Alsaadi, Gulcin Tezcan, Ekaterina E. Garanina, Shaimaa Hamza, Alan McIntyre, Albert A. Rizvanov, Svetlana F. Khaiboullina
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceuticals
Subjects:
doxycycline
nod-like receptor protein 3 (NLRP3)
inflammasome
apoptosis
cancer
Online Access:https://www.mdpi.com/1424-8247/14/9/852

Internet

https://www.mdpi.com/1424-8247/14/9/852

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