Molecular docking, QSAR, and ADME studies of some pyrrolo[1, 2-a] benzimidazole-based quinones as novel topoisomerase 2 beta (TOP2β) inhibitors

Molecular docking, QSAR, and ADME studies of some pyrrolo[1, 2-a] benzimidazole-based quinones as novel topoisomerase 2 beta (TOP2β) inhibitors

In recent years, selective topoisomerase II inhibitors have drawn interest in the development of novel antitumor compounds to an extraordinary degree. As potent topoisomerase II inhibitors, pyrrolo[1, 2-a]-benzimidazole quinones with a 6-aziridinyl group (PBIs) and a 6-acetamido group (APBIs) have b...

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Bibliographic Details
Main Authors: Rahul D. Jawarkar, Anam N. Khan, Dhanashri R. Bhagat, Pravin N. Khatale, Pramod V. Burakale, Saleemuddin Farooqui, Suraj N. Mali
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Chemical Physics Impact
Subjects:
PBIs
APBIs
DNA-topoisomerase II receptor
Anti-cancer
QSAR based virtual screening
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022424000239

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http://www.sciencedirect.com/science/article/pii/S2667022424000239

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