In silico identification of modulators of J domain protein-Hsp70 interactions in Plasmodium falciparum: a drug repurposing strategy against malaria

In silico identification of modulators of J domain protein-Hsp70 interactions in Plasmodium falciparum: a drug repurposing strategy against malaria

Plasmodium falciparum is a unicellular, intracellular protozoan parasite, and the causative agent of malaria in humans, a deadly vector borne infectious disease. A key phase of malaria pathology, is the invasion of human erythrocytes, resulting in drastic remodeling by exported parasite proteins, in...

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Bibliographic Details
Main Authors: Harpreet Singh, Shaikha Y. Almaazmi, Tanima Dutta, Robert A. Keyzers, Gregory L. Blatch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
Hsp70
J domain protein
pandemic response box
virtual screening
drug repurposing
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1158912/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1158912/full

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