Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.

Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.

X-linked inhibitor of apoptosis protein (XIAP) is constitutively expressed endogenous inhibitor of apoptosis, exhibit its antiapoptotic effect by inactivating key caspases such as caspase-3, caspase-7 and caspase-9 and also play pivotal role in rendering cancer chemoresistance. Our studies showed th...

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Bibliographic Details
Main Authors: Shashi Rajput, B N Prashanth Kumar, Siddik Sarkar, Subhasis Das, Belal Azab, Prasanna K Santhekadur, Swadesh K Das, Luni Emdad, Devanand Sarkar, Paul B Fisher, Mahitosh Mandal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3629226?pdf=render

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http://europepmc.org/articles/PMC3629226?pdf=render

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