New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling

New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling

Deoxycholic acid derivatives containing various heterocyclic functional groups at C-3 on the steroid scaffold were designed and synthesized as promising dual tyrosyl-DNA phosphodiesterase 1 and 2 (TDP1 and TDP2) inhibitors, which are potential targets to potentiate topoisomerase poison antitumor the...

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Bibliographic Details
Main Authors: Oksana V. Salomatina, Tatyana E. Kornienko, Alexandra L. Zakharenko, Nina I. Komarova, Chigozie Achara, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Molecules
Subjects:
deoxycholic acid
oxirane
thiols
TDP1 inhibitor
TDP2 inhibitor
cancer
Online Access:https://www.mdpi.com/1420-3049/29/3/581

Internet

https://www.mdpi.com/1420-3049/29/3/581

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