Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Abstract Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), are involved in mediating fundamental innate antimicrobial...

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Bibliographic Details
Main Authors: Juyan Zheng, Junluan Mo, Tao Zhu, Wei Zhuo, Yueneng Yi, Shuo Hu, Jiye Yin, Wei Zhang, Honghao Zhou, Zhaoqian Liu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Cancer
Subjects:
cGAS-STING
Innate immunity
Type I interferon
STING agonists
Antitumor response
Cancer development
Online Access:http://link.springer.com/article/10.1186/s12943-020-01250-1

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http://link.springer.com/article/10.1186/s12943-020-01250-1

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