Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis

Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis

In eukaryotic motile cells, the active Ras (Ras-GTP)-enriched domain is generated in an asymmetric manner on the cell membrane through the excitable dynamics of an intracellular signaling network. This asymmetric Ras signaling regulates pseudopod formation for both spontaneous random migration and c...

Full description

Bibliographic Details
Main Authors: Da Young Shin, Hiroaki Takagi, Michio Hiroshima, Satomi Matsuoka, Masahiro Ueda
Format: Article
Language:English
Published: Japan Society for Cell Biology 2023-07-01
Series:Cell Structure and Function
Subjects:
cell polarity
cell migration
ras
excitability
sphingomyelin
Online Access:https://www.jstage.jst.go.jp/article/csf/48/2/48_23045/_html/-char/en

Internet

https://www.jstage.jst.go.jp/article/csf/48/2/48_23045/_html/-char/en

Similar Items