294 Identification of MCAK Inhibitors that Induce Aneuploidy in Triple Negative Breast Cancer Models

294 Identification of MCAK Inhibitors that Induce Aneuploidy in Triple Negative Breast Cancer Models

OBJECTIVES/GOALS: Microtubule poisons, like Taxol, are used to treat triple negative breast cancer (TNBC) and may induce lethal aneuploidy in cancer cells. Patients initially respond, but often develop drug resistance. New targeted drugs that cause aneuploidy may be a valuable approach to therapy. O...

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Bibliographic Details
Main Authors: John Smith, Stefan Husted, Jay Pilrose, Disha Kuchangi, Stephanie C. Ems-McClung, Richard L. Carpenter, Claire E. Walczak
Format: Article
Language:English
Published: Cambridge University Press 2023-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866123003497/type/journal_article

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https://www.cambridge.org/core/product/identifier/S2059866123003497/type/journal_article

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