The deficiency in Th2-like Tfh cells affects the maturation and quality of HIV-specific B cell response in viremic infection

The deficiency in Th2-like Tfh cells affects the maturation and quality of HIV-specific B cell response in viremic infection

Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B cells. We have found that the expression of CXCR3 defines distinct Tfh subsets: CXCR3+ Th1-like Tfh cells mainly producing single IFN-γ and...

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Bibliographic Details
Main Authors: Alessandra Noto, Madeleine Suffiotti, Victor Joo, Antonio Mancarella, Francesco A. Procopio, Guy Cavet, Yvonne Leung, Jean-Marc Corpataux, Matthias Cavassini, Agostino Riva, Leonidas Stamatatos, Raphael Gottardo, Adrian B. McDermott, Richard A. Koup, Craig Fenwick, Matthieu Perreau, Giuseppe Pantaleo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
lymph nodes
follicular T helper cells
germinal center B cells (GC B cells)
HIV-1 infection
T helper cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.960120/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.960120/full

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