Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia

Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia

Pancreatic stellate cells (PSC) play a major role in the formation of fibrotic tissue in pancreatic tumors. On its side, melatonin is a putative therapeutic agent for pancreatic cancer and inflammation. In this work, the actions of melatonin on PSC subjected to hypoxia were evaluated. Reactive oxyge...

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Bibliographic Details
Main Authors: Matias Estaras, Manuel R. Gonzalez-Portillo, Remigio Martinez, Alfredo Garcia, Mario Estevez, Miguel Fernandez-Bermejo, Jose M. Mateos, Daniel Vara, Gerardo Blanco-Fernández, Diego Lopez-Guerra, Vicente Roncero, Gines M. Salido, Antonio Gonzalez
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
cell viability
glutathione
hypoxia
inflammation
melatonin
pancreatic stellate cells
Online Access:https://www.mdpi.com/2076-3921/10/4/577

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https://www.mdpi.com/2076-3921/10/4/577

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