Functional Mapping of Adhesiveness on Live Cells Reveals How Guidance Phenotypes Can Emerge From Complex Spatiotemporal Integrin Regulation

Functional Mapping of Adhesiveness on Live Cells Reveals How Guidance Phenotypes Can Emerge From Complex Spatiotemporal Integrin Regulation

Immune cells have the ubiquitous capability to migrate disregarding the adhesion properties of the environment, which requires a versatile adaptation of their adhesiveness mediated by integrins, a family of specialized adhesion proteins. Each subtype of integrins has several ligands and several affi...

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Bibliographic Details
Main Authors: Philippe Robert, Martine Biarnes-Pelicot, Nicolas Garcia-Seyda, Petra Hatoum, Dominique Touchard, Sophie Brustlein, Philippe Nicolas, Bernard Malissen, Marie-Pierre Valignat, Olivier Theodoly
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
adhesiveness
integrin affinity
LFA-1
VLA-4
lymphocyte
crosstalk
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.625366/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.625366/full

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