Restraint upon Embryonic Metatarsal <i>Ex Vivo</i> Growth by Hydrogel Reveals Interaction between Quasi-Static Load and the mTOR Pathway

Restraint upon Embryonic Metatarsal <i>Ex Vivo</i> Growth by Hydrogel Reveals Interaction between Quasi-Static Load and the mTOR Pathway

Mechanical cues play a vital role in limb skeletal development, yet their influence and underpinning mechanisms in the regulation of endochondral ossification (EO) processes are incompletely defined. Furthermore, interactions between endochondral growth and mechanics and the mTOR/NF-ĸB pathways are...

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Bibliographic Details
Main Authors: Soraia Caetano-Silva, Bigboy H. Simbi, Neil Marr, Andrew Hibbert, Steve P. Allen, Andrew A. Pitsillides
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
endochondral ossification
mTOR
NF-ĸB
quasi-static
loading
hydrogel
Online Access:https://www.mdpi.com/1422-0067/22/24/13220

Internet

https://www.mdpi.com/1422-0067/22/24/13220

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