Advanced glycation end products impair bone marrow mesenchymal stem cells osteogenesis in periodontitis with diabetes via FTO-mediated N 6-methyladenosine modification of sclerostin

Advanced glycation end products impair bone marrow mesenchymal stem cells osteogenesis in periodontitis with diabetes via FTO-mediated N 6-methyladenosine modification of sclerostin

Abstract Background Diabetes mellitus (DM) and periodontitis are two prevalent diseases with mutual influence. Accumulation of advanced glycation end products (AGEs) in hyperglycemia may impair cell function and worsen periodontal conditions. N 6-methyladenosine (m6A) is an important post-transcript...

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Bibliographic Details
Main Authors: Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Guangyue Li, Leilei Zheng, Jinlin Song
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Translational Medicine
Subjects:
Diabetes mellitus
Periodontitis
Bone marrow mesenchymal stem cells
Osteogenesis
Advanced glycation end products
N 6-methyladenosine
Online Access:https://doi.org/10.1186/s12967-023-04630-5

Internet

https://doi.org/10.1186/s12967-023-04630-5

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