Comprehensive Flux Modeling of Chlamydia trachomatis Proteome and qRT-PCR Data Indicate Biphasic Metabolic Differences Between Elementary Bodies and Reticulate Bodies During Infection

Comprehensive Flux Modeling of Chlamydia trachomatis Proteome and qRT-PCR Data Indicate Biphasic Metabolic Differences Between Elementary Bodies and Reticulate Bodies During Infection

Metabolic adaptation to the host cell is important for obligate intracellular pathogens such as Chlamydia trachomatis (Ct). Here we infer the flux differences for Ct from proteome and qRT-PCR data by comprehensive pathway modeling. We compare the comparatively inert infectious elementary body (EB) a...

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Bibliographic Details
Main Authors: Manli Yang, Karthika Rajeeve, Thomas Rudel, Thomas Dandekar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Microbiology
Subjects:
Chlamydia trachomatis
metabolic modeling
metabolic flux
infection biology
elementary body
reticulate body
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02350/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02350/full

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