Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics

Recombinant T-cells receptors can redirect naïve T cells but often have low or uneven expression. Here, the authors model mutations in TCR constant domains to increase T cell receptor expression, assembly, and stability and generate bispecific molecules.

Bibliographic Details
Main Authors: Karen Froning, Jack Maguire, Arlene Sereno, Flora Huang, Shawn Chang, Kenneth Weichert, Anton J. Frommelt, Jessica Dong, Xiufeng Wu, Heather Austin, Elaine M. Conner, Jonathan R. Fitchett, Aik Roy Heng, Deepa Balasubramaniam, Mark T. Hilgers, Brian Kuhlman, Stephen J. Demarest
Format: Article
Language:English
Published: Nature Portfolio 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16231-7

Internet

https://doi.org/10.1038/s41467-020-16231-7

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