Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth <it>in vitro </it>and <it>in vivo</it>

Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth <it>in vitro </it>and <it>in vivo</it>

<p>Abstract</p> <p>Background</p> <p>Advanced melanoma is characterized by a pronounced resistance to therapy leading to a limited patient survival of ~6 - 9 months. Here, we report on a novel bifunctional therapeutic fusion protein, designated anti-MCSP:TRAIL, that is...

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Bibliographic Details
Main Authors: van Waarde Aren, Dierckx Rudi AJO, Fey Georg H, Schwenkert Michael, Wei Yunwei, Rybczynska Anna A, de Bruyn Marco, Helfrich Wijnand, Bremer Edwin
Format: Article
Language:English
Published: BMC 2010-11-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/301

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http://www.molecular-cancer.com/content/9/1/301

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