p27kip1 expression and phosphorylation dictate Palbociclib sensitivity in KRAS-mutated colorectal cancer

p27kip1 expression and phosphorylation dictate Palbociclib sensitivity in KRAS-mutated colorectal cancer

Abstract In colorectal cancer, mutation of KRAS (RASMUT) reduces therapeutic options, negatively affecting prognosis of the patients. In this setting, administration of CDK4/6-inhibitors, alone or in combination with other drugs, is being tested as promising therapeutic strategy. Identifying sensiti...

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Bibliographic Details
Main Authors: Gian Luca Rampioni Vinciguerra, Alessandra Dall’Acqua, Ilenia Segatto, Maria Chiara Mattevi, Francesca Russo, Andrea Favero, Roberto Cirombella, Giorgia Mungo, Davide Viotto, Javad Karimbayli, Margherita Pesce, Andrea Vecchione, Barbara Belletti, Gustavo Baldassarre
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04241-2

Internet

https://doi.org/10.1038/s41419-021-04241-2

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