FSTL1-USP10-Notch1 Signaling Axis Protects Against Cardiac Dysfunction Through Inhibition of Myocardial Fibrosis in Diabetic Mice

FSTL1-USP10-Notch1 Signaling Axis Protects Against Cardiac Dysfunction Through Inhibition of Myocardial Fibrosis in Diabetic Mice

The incidence of type 2 diabetes mellitus (T2DM) has been increasing globally, and T2DM patients are at an increased risk of major cardiac events such as myocardial infarction (MI). Nevertheless, the molecular mechanisms underlying MI injury in T2DM remain elusive. Ubiquitin-specific protease 10 (US...

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Bibliographic Details
Main Authors: Linhe Lu, Jipeng Ma, Yang Liu, Yalan Shao, Xiang Xiong, Weixun Duan, Erhe Gao, Qianli Yang, Shasha Chen, Jian Yang, Jun Ren, Qijun Zheng, Jincheng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
fibrosis
follistatin-like protein 1
ubiquitin-specific protease 10
apoptosis
diabetes cardiomyopathy
myocardial infarction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.757068/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.757068/full

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