CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they can be readily engineered to express multiple large transgenes. However, the integration of multiple payloads into poxvir...

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Bibliographic Details
Main Authors: Jack T. Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A. Tamming, Giuseppe Pugliese, Nikolas T. Martin, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E. F. Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S. Huh, Matt Y. Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D. Lichty, Carolina S. Ilkow, John C. Bell
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9)
vaccinia virus (VACV)
STING agonist
poxvirus
oncolytic virus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050250/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050250/full

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