Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype and homozygosity leads to embryonic lethality. To understand the role of Apc...

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Bibliographic Details
Main Authors: Mari Kuraguchi, Xiu-Ping Wang, Roderick T Bronson, Rebecca Rothenberg, Nana Yaw Ohene-Baah, Jennifer J Lund, Melanie Kucherlapati, Richard L Maas, Raju Kucherlapati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1564426?pdf=render

Internet

http://europepmc.org/articles/PMC1564426?pdf=render

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