Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype and homozygosity leads to embryonic lethality. To understand the role of Apc...

Full description

Bibliographic Details
Main Authors:	Mari Kuraguchi, Xiu-Ping Wang, Roderick T Bronson, Rebecca Rothenberg, Nana Yaw Ohene-Baah, Jennifer J Lund, Melanie Kucherlapati, Richard L Maas, Raju Kucherlapati
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2006-09-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC1564426?pdf=render

Similar Items

Genetic mechanisms in Apc-mediated mammary tumorigenesis.
by: Mari Kuraguchi, et al.
Published: (2009-02-01)

Adenomatous Polyposis Coli (APC) in cell migration
by: Xingyuan Fang, et al.
Published: (2022-06-01)

Familial adenomatous polyposis (FAP) and its gene, APC.
by: Bodmer, W
Published: (1999)

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
by: Sieber, O, et al.
Published: (2000)

Wild-type APC Influences the Severity of Familial Adenomatous Polyposis
by: Krzysztof Flisikowski, et al.
Published: (2022-01-01)

Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.
by: Jean Schneikert, et al.
Published: (2013-01-01)

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
by: Imelda T Sandoval, et al.
Published: (2017-04-01)

A neoepitope derived from a novel germline Adenomatous polyposis coli (APC) gene mutation in Familial Adenomatous Polyposis (FAP) shows selective immunogenicity
by: Snigdha Majumder, et al.
Published: (2017-12-01)

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
by: Cottrell, S, et al.
Published: (1992)

Pathogenic <i>APC</i> Variants in Latvian Familial Adenomatous Polyposis Patients
by: Zanda Daneberga, et al.
Published: (2019-09-01)

Familial adenomatous polyposis associated APC gene mutation - A case study
by: Avinash Bardia1, Santosh K. Tiwari1, Sandeep K. Vishwakarma1, Md. Aejaz Habeeb1, Pratibha Nallari2, Aleem A. Khan1
Published: (2013-08-01)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.
by: Sieber, O, et al.
Published: (2002)

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas
by: Sieber, O, et al.
Published: (2002)

Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells.
by: Cesar A Sommer, et al.
Published: (2018-01-01)

Familial adenomatous polyposis coli
by: K Boeren, et al.
Published: (2011-03-01)

The fluctuation of APC gene in WNT signaling with adenine deletion of adenomatous polyposis coli, is associated in colorectal cancer
by: Seyedeh Elham Norollahi, et al.
Published: (2020-04-01)

Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions.
by: Alexander D Karabachev, et al.
Published: (2020-01-01)

Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
by: Sturt, N, et al.
Published: (2004)

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes
by: Giovanna Forte, et al.
Published: (2023-07-01)

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis
by: Juyi Li, et al.
Published: (2023-07-01)

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
by: Céline Cuche, et al.
Published: (2023-07-01)

Identification of mutation in 3'-end of exon 15 of APC gene in familial adenomatous polyposis patients
by: Habibollahi H, et al.
Published: (2020-02-01)

Complete deletion of Apc results in severe polyposis in mice
by: Bronson, Roderick T., et al.
Published: (2014)

Familial adenomatous polyposis
by: Rozen Paul, et al.
Published: (2009-10-01)

Germline mutation at codon 1309 of the adenomatous polyposis coli gene and exteracolonic manifestations in familial adenomatous polyposis
by: Faegheh Behboudi Farahbakhsh, et al.
Published: (2017-07-01)

Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function
by: Marcia Roxana Cruz-Correa, et al.
Published: (2020-02-01)

The Tumor Suppressor <i>Adenomatous Polyposis Coli (apc)</i> Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
by: Xiaolei Liu, et al.
Published: (2023-06-01)

The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma
by: Georgia Sofia Karachaliou, et al.
Published: (2022-01-01)

Adenomatous polyposis coli in cancer and therapeutic implications
by: Olivia Noe, et al.
Published: (2021-06-01)

Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes
by: Scott Rodney J
Published: (2003-12-01)

Investigation of Mutation in a Part of Exon 15 of APC Gene in Patients with Familial Adenomatous Polyposis in Gilan Province
by: M Ahmad Sharbafi, et al.
Published: (2017-12-01)

Genotype directed therapy in murine mismatch repair deficient tumors.
by: Melanie H Kucherlapati, et al.
Published: (2013-01-01)

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish
by: Alexander J. Valvezan, et al.
Published: (2014-01-01)

Genomic insights into familial adenomatous polyposis: unraveling a rare case with whole APC gene deletion and intellectual disability
by: Hiroki Tanabe, et al.
Published: (2024-03-01)

The in vivo rate of somatic adenomatous polyposis coli mutation.
by: Hornsby, C, et al.
Published: (2008)

Familial adenomatous polyposis and desmoid tumors
by: Ana Elisa Moraes Righetti, et al.
Published: (2011-01-01)

Identification of 5 novel germline <it>APC </it>mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis
by: Mori Hiroki, et al.
Published: (2010-11-01)

Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome
by: Christina Lui, et al.
Published: (2016-04-01)

Adenomatous Polyposis Coli Mutation Leads to Myopia Development in Mice.
by: Zhen Liu, et al.
Published: (2015-01-01)

Molecular Pathways of Carcinogenesis in Familial Adenomatous Polyposis
by: Ilaria Ditonno, et al.
Published: (2023-03-01)