HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanismsResearch in context

HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanismsResearch in context

Summary: Background: HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based HFrEF subphenotypes and to investigate underlying dynamic biological mechanisms. Herewith we aimed to gain pathophysiological...

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Bibliographic Details
Main Authors: Teun B. Petersen, Marie de Bakker, Folkert W. Asselbergs, Magdalena Harakalova, K. Martijn Akkerhuis, Jasper J. Brugts, Jan van Ramshorst, R. Thomas Lumbers, Rachel M. Ostroff, Peter D. Katsikis, Peter J. van der Spek, Victor A. Umans, Eric Boersma, Dimitris Rizopoulos, Isabella Kardys
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:EBioMedicine
Subjects:
Proteomics
Biomarkers
Phenotypes
Unsupervised machine learning
Heart Failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423002207

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http://www.sciencedirect.com/science/article/pii/S2352396423002207

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